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CDC, FDA recommend 3rd COVID vaccine dose for immune-compromised

CDC, FDA recommend 3rd COVID vaccine dose for immune-compromised

Moderately and severely immunocompromised adults should receive a third dose of a COVID-19 mRNA vaccine, the Advisory Committee on Immunization Practices (ACIP) advised today following the Food and Drug Administration’s (FDA’s) authorization of third shots late yesterday.

A third dose should be given at least 28 days after the initial vaccinations series is complete, and the same vaccine should be used when possible, according to the FDA. In addition, the ACIP said that the additional dose would be given ideally 2 weeks before the start of immunosuppressive therapies.

The ACIP said recent data show third doses significantly boost the effectiveness of mRNA vaccines in this population, which includes those who have had an organ transplant, HIV patients, cancer patients, and people taking high-dose steroids or other immunosuppressive drugs.

During the ACIP meeting, Camille Kotton, MD, of the Massachusetts General Hospital transplant clinic, said she is seeing more immunocompromised, fully vaccinated patients require hospitalization for breakthrough COVID-19 infections.

Currently, immunocompromised people make up 40% to 44% of hospitalized breakthrough infections in the United States, according to a slide shared at the ACIP meeting. Studies have shown that the vaccines are only 59% 72% effective after two doses in this group, as opposed to 90% to 94% effective in healthy adults.

ACIP members discussed immunocompromised people who got the Johnson & Johnson vaccine. So far, they said, the FDA has not yet offered guidance to this group of people, which is likely small as immunocompromised people were among the first groups to get vaccinated and were likely given the mRNA vaccines.

During the ACIP meeting, members discussed how immunocompromised patients seeking third doses will be identified and concluded that it would be on an honor system.

The latest data from the Centers for Disease Control and Prevention (CDC) COVID Data Tracker shows 411,253,925 COVID-19 vaccine doses have been delivered and 353,859,894 have been administered in the United States, with 50.4% of Americans fully vaccinated (59.2% have received at least one dose).

Hot spots include Oregon, Hawaii

The pandemic continues to surge through the United States, with 8 states now accounting for 51% of the national cases, according to a CNN analysis of Department of Health and Human Services data.

Those states, Alabama, Arkansas, Florida, Georgia, Louisiana, Mississippi, Nevada, and Texas, also have some of the lowest vaccination rates in the country. But two states with relatively high vaccine uptake—Hawaii and Oregon—are also reporting a jump in cases that is leaving hospitals vulnerable. Oregon now has more hospitalization than at any point in the pandemic, and Hawaii soon will. Intensive care unit beds are now 90% full in Hawaii.

Yesterday the United States reported 116,545 new COVID-19 cases and 616 deaths yesterday, according to the Johns Hopkins COVID-19 tracker. The 7-day average of new cases is 121,556, according to the Washington Post tracker.

San Fran to require proof of vaccination

Leaders in San Francisco announced yesterday that the city will require indoor public settings, including restaurants, bars, nightclubs, theaters, entertainment venues, and gyms, to obtain proof of full vaccination from patrons and employees beginning Aug 20. 

“We know that for our city to bounce back from the pandemic and thrive, we need to use the best method we have to fight COVID-19 and that’s vaccines,” said Mayor London Breed in a press statement. “Vaccines are our way out of the pandemic, and our way back to a life where we can be together safely.”

In related news, the National Education Association (NEA) said yesterday that it would support policies that require all teachers to get vaccinated against the coronavirus or submit to regular testing, the New York Times reports. Earlier this week, NEA head Randi Weingarten said she now supported the idea of vaccine mandates in light of recent virus surges. 

Supreme Court Justice Amy Coney Barrett yesterday rejected a plea from a group of Indiana University students to stop the university’s vaccine requirement, the Washington Post reports. The matter was not referred to the other justices, a signal that the student’s argument did not have firm legal standing.

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